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Herpes Cure And Treatment

False Positive Hsv Culture But Neg Blood Test

The major disadvantage of the culture is its high rate of false negatives. Blood tests can be used when a person has no visible symptoms but has concerns about having herpes. A person who only has HSV-1 may receive a false positive for HSV-2. PCR blood test: The PCR blood test can tell if you have genital herpes even if you don’t have symptoms. Cell culture or PCR test may give a false-negative result if the sores have begun healing or if you are recently infected. If you test positive, but your risk for getting the virus is low, you may need to be tested again.

Basically, if you test positive for herpes type 1 and negative for 2 that does not mean you don’t have genital herpes. Herpes blood tests are not screening tests, but tests that should be used to answer a specific problem. So what is the explanation for a positive culture and a negative IGg for 6 years. How likely is it for the IgG test to give a false negative, especially 8 months after the initial infection which was diagnosed with a swab test, and when earlier IgG’s were equivocal? Did someone just botch up the blood test last week? I’ve been taking 500 Valtrex daily since the initial outbreak to prevent recurrences in the first year. I asked my doctor if my culture could be a false positive. or maybe blood can be false negative. Or maybe blood can be false negative. A postive culture and a negative blood test USUALLY mean you just got this recently. My results says i’m positive for hsv-1, but negative for hsv-2. Most (90 in one study) of these people have positive blood tests for HSV with no history of symptoms or outbreaks. Many such persons have mild or unrecognized infections but shed virus intermittently in the genital tract. There are three main laboratory methods to diagnose the virus: culture, PCR, and blood tests for antibodies, although false negative results are possible.

Understanding Blood Tests For Herpes

If a viral culture taken at a clinic from an active herpes lesion is positive for herpes simplex, then this makes the diagnosis. Sadly, the viral culture can be falsely negative for many reasons. My recommendation on so-called type-specific EIA test blood work, which means any blood testing not discussed on these two pages, is not to do it. This could take as long as three months from the time of infection, but the mean time according to Wald et al in initial testing of this product was 13 days post exposure, though the variation was quite wide. Describes what herpes is and how the sample is collected for testing. False negatives can occur if there is not enough active virus in the test sample, which can occur if the lesion is cultured more than 48 hours after the symptoms appear. DNA testing is usually done only if the culture is negative but the practitioner still suspects herpes, or if the patient has received treatment for herpes. A positive herpes simplex culture or HSV DNA test from a vesicle scraping indicates an active HSV-1 or HSV-2 infection. Yeah but you know they don’t usually test for herpes right? Since I live an hour away from my gynecologist and was just looking for the most convenient way to get tested, I found a website that could send a lab order for the STD tests to my local walk-in lab, where I could get my blood drawn without having to make an appointment. For example, I didn’t test positive for HSV-1, so cross-reactivity with HSV-1 was out as a reason for my potential false positive. I know I had a negative culture swab at one point.

And false negatives on herpes blood and culture tests are very, very common. Secondary outbreaks last shorter amounts of time, but still suck ass. You can test false positive, or false negative, over and over, whether or not you exhibit the classical signs of herpes. Should I trust the negative results of my HSV blood and culture tests? So I let it be, but then when I moved into a new town I consulted with my new gynecologist and she indicated that just in case I should have an Herpselect ELISA blood test run to discard the chance that it could be herpes. 2) We don’t know why some people get false positives. I understand that a culture test is more reliable, but is there precedent for a false positive on that? But the last 2 outbreaks I’ve had have come back Positive for HSV-2 when swabbed and Negative for HSV-2 when blood is drawn (tests taken at the same time). However the blood test showed + HSV-1 and – (negative) for HSV-2. Your lesion cultures being positive means you really do have hsv2. you have no reason to doubt that at all. If you started looking closely at the false negative odds for mammograms, pap tests, biopsy’s, blood work etc, you’d start wondering why you even bother to go to a doctor and don’t just go back to the old days when you went to the local barber and they just cut your skin and let you bleed the demons out and hope you survived to tell the tale. False: A negative blood test or negative culture means you don’t have herpes. The development of highly sensitive, type-specific serologic (blood) tests for herpes in recent years is certainly an important breakthrough in accurately diagnosing herpes. If you have a positive test with a PCR or a culture, you really don’t need serology. Wait until the lesion has begun to heal, and the result may be a false negative. But what about those without symptoms, who may have other reasons for getting tested? For those people, Dr.

What No One Ever Tells You About Genital Herpes: My Personal Experience

They include a physical examination, swab tests, and/or a blood test. One study found that herpes cultures give FALSE NEGATIVE results 76 of the time when compared to the more accurate PCR test described below. This test is definitely not as desirable as a culture or PCR, but a positive Tzanck, read by an experienced lab person, combined with a good physical exam, sexual history and the presence of symptoms consistent with herpes infection is reasonably accurate. As many as one in five adults have genital herpes due to HSV-2, but most will have asymptomatic or unrecognised disease. HSV isolation in cell culture has been the diagnostic gold standard for many years. Serological tests detect antibodies to HSV in blood and indicate past infection. False negative and false positive results are common in low prevalence populations and there is no confirmatory serology testing available in New Zealand. Since you’ve had at least 2 outbreaks, and a positive culture, odds are the blood test is giving you a false negative, but I don’t think anyone can fault you for wanting confirmation to make sure there wasn’t a mixup with the swab culture. HSV-2 rarely infects oral tissue, though, and a blood test positive for HSV-2 typically indicates that an individual has genital herpes, even if they’ve never experienced symptoms. Blood tests also can be used when a person has no visible symptoms but has concerns about having herpes. So even with the accurate tests, a person could receive a false negative if the test is taken too soon after contracting the virus. You may want to ask for a herpes culture test if you have any open sores or bumps on your genitalia. Herpes type 2 is much less common, but it’s still out there. A positive culture is real and reliable, however a negative culture does not mean you don’t have it. The false negative rate for cultures is high. We test for both Herpes types by culture and by blood to help figure out which virus is responsible for the outbreak. In the past, genital herpes was mostly caused by HSV-2, but HSV-1 genital infection is increasing. False-negative (testing negative when herpes infection is actually present) results can occur if tests are done in the early stages of infection. False-positive results (testing positive when herpes infection is not actually present) can also occur, although less often than false-negative. Detailed fact sheets include specific testing and treatment recommendations as well as citations so the reader can research the topic more in depth. Both HSV-1 and HSV-2 can also cause rare but serious complications such as blindness, encephalitis (inflammation of the brain) , and aseptic meningitis (inflammation of the linings of the brain). However, false positive HSV-2 ELISA results are more often seen when testing is done in populations with a lower prevalence of HSV-2. Several scenarios where type-specific HSV tests may be useful includePatients with recurrent genital symptoms or atypical symptoms and negative HSV cultures; I tested negative for everything- except Herpes 2 (HSV-2) (I had the blood test, not a swab test, and I’ve never had anything remotely approaching symptoms. Just to be clear: my doctor said I had antibodies in my blood for HSV-2, but I’ve seen some articles online saying that Zoster can be confused for Herpes 2 and I would really, REALLY like to rule out any alternative possibilities. If you have no history of genital herpes outbreaks, did not have a positive culture or PCR test for HSV, or have no risk factors for genital herpes, you should know the index value. There are two types of herpes tests readily available, a culture and a blood test. If the test is positive, it is a true positive, meaning that you do have herpes. If test is negative, it may be a false negative, meaning you may or may not have herpes. But other times there may be a cross reaction with other herpes viruses such as chicken pox (herpes zoster) or mononucleosis (Epstein-Barr virus) , giving a false positive result. Blood donor sera were assayed for HSV-2 antibodies by both methods. One of the eight false-positive test results was equivocal. To earn CEUs, visit mlo-online. com and see this month’s test by clicking the CE menu item. Other considerations include the cost of false positives or false negatives, which may be difficult to quantify, the value of superior service to clinician clients, and the laboratory’s reputation for quality and service. Recent CDC guidelines include both culture and molecular methods for HSV testing, but note that the sensitivity of viral culture is low, especially for recurrent lesions, and declines rapidly as lesions begin to heal. Please feel free to write me at alenhoffmlo-online. com to express what your lab’s experience has been with either of these two alternatives. Cultures can also be taken when you are asymptomatic to determine whether you are shedding the virus. I have had two positive blood tests for the genital herpes virus, but no positive cultures of any kind. And yes, there can always be false positives and false negatives, as with nearly any test.

Resources

False Positive Hsv Culture But Neg Blood Test

The major disadvantage of the culture is its high rate of false negatives. Blood tests can be used when a person has no visible symptoms but has concerns about having herpes. A person who only has HSV-1 may receive a false positive for HSV-2. PCR blood test: The PCR blood test can tell if you have genital herpes even if you don’t have symptoms. Cell culture or PCR test may give a false-negative result if the sores have begun healing or if you are recently infected. If you test positive, but your risk for getting the virus is low, you may need to be tested again.

Basically, if you test positive for herpes type 1 and negative for 2 that does not mean you don’t have genital herpes. Herpes blood tests are not screening tests, but tests that should be used to answer a specific problem. So what is the explanation for a positive culture and a negative IGg for 6 years. How likely is it for the IgG test to give a false negative, especially 8 months after the initial infection which was diagnosed with a swab test, and when earlier IgG’s were equivocal? Did someone just botch up the blood test last week? I’ve been taking 500 Valtrex daily since the initial outbreak to prevent recurrences in the first year. I asked my doctor if my culture could be a false positive. or maybe blood can be false negative. Or maybe blood can be false negative. A postive culture and a negative blood test USUALLY mean you just got this recently. My results says i’m positive for hsv-1, but negative for hsv-2. Most (90 in one study) of these people have positive blood tests for HSV with no history of symptoms or outbreaks. Many such persons have mild or unrecognized infections but shed virus intermittently in the genital tract. There are three main laboratory methods to diagnose the virus: culture, PCR, and blood tests for antibodies, although false negative results are possible.

Understanding Blood Tests For Herpes

If a viral culture taken at a clinic from an active herpes lesion is positive for herpes simplex, then this makes the diagnosis. Sadly, the viral culture can be falsely negative for many reasons. My recommendation on so-called type-specific EIA test blood work, which means any blood testing not discussed on these two pages, is not to do it. This could take as long as three months from the time of infection, but the mean time according to Wald et al in initial testing of this product was 13 days post exposure, though the variation was quite wide. Describes what herpes is and how the sample is collected for testing. False negatives can occur if there is not enough active virus in the test sample, which can occur if the lesion is cultured more than 48 hours after the symptoms appear. DNA testing is usually done only if the culture is negative but the practitioner still suspects herpes, or if the patient has received treatment for herpes. A positive herpes simplex culture or HSV DNA test from a vesicle scraping indicates an active HSV-1 or HSV-2 infection. Yeah but you know they don’t usually test for herpes right? Since I live an hour away from my gynecologist and was just looking for the most convenient way to get tested, I found a website that could send a lab order for the STD tests to my local walk-in lab, where I could get my blood drawn without having to make an appointment. For example, I didn’t test positive for HSV-1, so cross-reactivity with HSV-1 was out as a reason for my potential false positive. I know I had a negative culture swab at one point.

And false negatives on herpes blood and culture tests are very, very common. Secondary outbreaks last shorter amounts of time, but still suck ass. You can test false positive, or false negative, over and over, whether or not you exhibit the classical signs of herpes. Should I trust the negative results of my HSV blood and culture tests? So I let it be, but then when I moved into a new town I consulted with my new gynecologist and she indicated that just in case I should have an Herpselect ELISA blood test run to discard the chance that it could be herpes. 2) We don’t know why some people get false positives. I understand that a culture test is more reliable, but is there precedent for a false positive on that? But the last 2 outbreaks I’ve had have come back Positive for HSV-2 when swabbed and Negative for HSV-2 when blood is drawn (tests taken at the same time). However the blood test showed + HSV-1 and – (negative) for HSV-2. Your lesion cultures being positive means you really do have hsv2. you have no reason to doubt that at all. If you started looking closely at the false negative odds for mammograms, pap tests, biopsy’s, blood work etc, you’d start wondering why you even bother to go to a doctor and don’t just go back to the old days when you went to the local barber and they just cut your skin and let you bleed the demons out and hope you survived to tell the tale. False: A negative blood test or negative culture means you don’t have herpes. The development of highly sensitive, type-specific serologic (blood) tests for herpes in recent years is certainly an important breakthrough in accurately diagnosing herpes. If you have a positive test with a PCR or a culture, you really don’t need serology. Wait until the lesion has begun to heal, and the result may be a false negative. But what about those without symptoms, who may have other reasons for getting tested? For those people, Dr.

What No One Ever Tells You About Genital Herpes: My Personal Experience

They include a physical examination, swab tests, and/or a blood test. One study found that herpes cultures give FALSE NEGATIVE results 76 of the time when compared to the more accurate PCR test described below. This test is definitely not as desirable as a culture or PCR, but a positive Tzanck, read by an experienced lab person, combined with a good physical exam, sexual history and the presence of symptoms consistent with herpes infection is reasonably accurate. As many as one in five adults have genital herpes due to HSV-2, but most will have asymptomatic or unrecognised disease. HSV isolation in cell culture has been the diagnostic gold standard for many years. Serological tests detect antibodies to HSV in blood and indicate past infection. False negative and false positive results are common in low prevalence populations and there is no confirmatory serology testing available in New Zealand. Since you’ve had at least 2 outbreaks, and a positive culture, odds are the blood test is giving you a false negative, but I don’t think anyone can fault you for wanting confirmation to make sure there wasn’t a mixup with the swab culture. HSV-2 rarely infects oral tissue, though, and a blood test positive for HSV-2 typically indicates that an individual has genital herpes, even if they’ve never experienced symptoms. Blood tests also can be used when a person has no visible symptoms but has concerns about having herpes. So even with the accurate tests, a person could receive a false negative if the test is taken too soon after contracting the virus. You may want to ask for a herpes culture test if you have any open sores or bumps on your genitalia. Herpes type 2 is much less common, but it’s still out there. A positive culture is real and reliable, however a negative culture does not mean you don’t have it. The false negative rate for cultures is high. We test for both Herpes types by culture and by blood to help figure out which virus is responsible for the outbreak. In the past, genital herpes was mostly caused by HSV-2, but HSV-1 genital infection is increasing. False-negative (testing negative when herpes infection is actually present) results can occur if tests are done in the early stages of infection. False-positive results (testing positive when herpes infection is not actually present) can also occur, although less often than false-negative. Detailed fact sheets include specific testing and treatment recommendations as well as citations so the reader can research the topic more in depth. Both HSV-1 and HSV-2 can also cause rare but serious complications such as blindness, encephalitis (inflammation of the brain) , and aseptic meningitis (inflammation of the linings of the brain). However, false positive HSV-2 ELISA results are more often seen when testing is done in populations with a lower prevalence of HSV-2. Several scenarios where type-specific HSV tests may be useful includePatients with recurrent genital symptoms or atypical symptoms and negative HSV cultures; I tested negative for everything- except Herpes 2 (HSV-2) (I had the blood test, not a swab test, and I’ve never had anything remotely approaching symptoms. Just to be clear: my doctor said I had antibodies in my blood for HSV-2, but I’ve seen some articles online saying that Zoster can be confused for Herpes 2 and I would really, REALLY like to rule out any alternative possibilities. If you have no history of genital herpes outbreaks, did not have a positive culture or PCR test for HSV, or have no risk factors for genital herpes, you should know the index value. There are two types of herpes tests readily available, a culture and a blood test. If the test is positive, it is a true positive, meaning that you do have herpes. If test is negative, it may be a false negative, meaning you may or may not have herpes. But other times there may be a cross reaction with other herpes viruses such as chicken pox (herpes zoster) or mononucleosis (Epstein-Barr virus) , giving a false positive result. Blood donor sera were assayed for HSV-2 antibodies by both methods. One of the eight false-positive test results was equivocal. To earn CEUs, visit mlo-online. com and see this month’s test by clicking the CE menu item. Other considerations include the cost of false positives or false negatives, which may be difficult to quantify, the value of superior service to clinician clients, and the laboratory’s reputation for quality and service. Recent CDC guidelines include both culture and molecular methods for HSV testing, but note that the sensitivity of viral culture is low, especially for recurrent lesions, and declines rapidly as lesions begin to heal. Please feel free to write me at alenhoffmlo-online. com to express what your lab’s experience has been with either of these two alternatives. Cultures can also be taken when you are asymptomatic to determine whether you are shedding the virus. I have had two positive blood tests for the genital herpes virus, but no positive cultures of any kind. And yes, there can always be false positives and false negatives, as with nearly any test.

Resources

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